Fresenius Hemoflow F5 HPS Low-Flux Polysulfone Dialyzer
Pack Sizes Available
Product Description
Technical Specifications
- Membrane Material: Fresenius Polysulfone — proprietary microundulated hollow fibre structure
- Flux Type: Low-flux
- Effective Membrane Area: 1.0 m²
- Priming Volume: 63 mL
- Ultrafiltration Coefficient (Kuf): Approximately 10 mL/h x mmHg (F5 HPS)
- Sterilisation: INLINE Steam sterilisation — no chemical residuals, pyrogen-free
Frequently asked questions
Low-flux dialyzers have a relatively small membrane pore size that efficiently removes small molecular weight solutes (urea, creatinine, phosphate) through diffusion, but has limited capacity for removing middle molecules (beta-2 microglobulin, molecular weight ~11,800 Da). Low-flux dialysis is indicated for patients with adequate residual kidney function contributing to overall toxin clearance, patients on more frequent dialysis schedules where middle molecule accumulation is less of a concern, or clinical protocols where low-flux dialysis is the standard of care. High-flux dialyzers remove middle molecules more effectively and are generally associated with better long-term outcomes in patients with ESRD.
The 1.0 m² designation indicates the effective mass transfer area of the hollow fibre membrane inside the F5 dialyzer. This surface area determines the maximum rate of solute diffusion from blood to dialysate at given blood and dialysate flow rates. The F5 is smaller than the F6 (1.3 m²) and F8 (1.8 m²). Surface area selection is matched to patient body surface area and target dialysis dose (Kt/V). Smaller patients or patients with smaller blood volumes benefit from smaller surface area dialyzers because they reduce the extracorporeal blood volume (priming volume 63 mL for F5) while still achieving adequate Kt/V for their lower total body water.
INLINE steam sterilisation of the F-series HPS dialyzers passes steam at 121°C or higher directly through both the blood and dialysate compartments of the assembled dialyzer. This eliminates chemical sterilisation residues (ETO leaves residual ethylene oxide that requires degassing periods and has been associated with adverse reactions in some patients) and avoids the material property changes that gamma irradiation causes in polysulfone membranes. Steam-sterilised dialyzers have been shown in studies to produce lower levels of oxidative stress biomarkers in patient blood compared to gamma-sterilised equivalents, which may have clinical relevance in patient populations where oxidative stress contributes to cardiovascular risk.
The ultrafiltration coefficient (Kuf) of the Fresenius F5 HPS is approximately 10 mL/h x mmHg. This means that for every 1 mmHg of transmembrane pressure, the membrane permits approximately 10 mL/hour of fluid filtration. The low Kuf of the low-flux F5 means that transmembrane pressure control during the dialysis session is straightforward — small changes in TMP produce small changes in ultrafiltration rate, giving the clinical team good control of the fluid removal rate without fine TMP adjustment. High-flux dialyzers with Kuf values of 20-50+ mL/h x mmHg require more careful TMP management.
Dialyzer reuse protocols have historically been practised in some healthcare systems to reduce the per-treatment cost of dialysis, where the dialyzer is reprocessed with chemical disinfection between sessions on the same patient (never between different patients). However, reuse guidelines vary significantly by country and institution, and many dialysis systems now operate exclusively with single-use dialyzers for infection control, regulatory, and liability reasons. Fresenius Medical Care's dialyzers are manufactured and marketed as single-use devices; any reuse is subject to local regulatory approval and must follow validated reprocessing protocols. Confirm local regulations and institutional policy before implementing any dialyzer reuse programme.
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