Fresenius F6 HPS Polysulfone Low-Flux Dialyzer
Pack Sizes Available
Product Description
Technical Specifications
- Membrane Material: Fresenius Polysulfone — microundulated hollow fibre, high endotoxin retention
- Flux Type: Low-flux
- Effective Membrane Area: 1.3 m²
- Priming Volume: 82 mL
- Ultrafiltration Coefficient (Kuf): 13 mL/h x mmHg
- Urea Clearance: 186 mL/min @ QB 200 mL/min; 222 mL/min @ QB 300 mL/min
Frequently asked questions
The Fresenius Polysulfone hollow fibres in F-series dialyzers have a wavy (microundulated) geometry rather than a straight cylindrical shape. When fibres are straight, dialysate flowing through the bundle tends to create preferential channels between fibres — the dialysate follows paths of least resistance, bypassing some fibres and creating areas of low dialysate contact that reduce effective membrane utilisation. The undulating fibre structure forces the dialysate to follow a more tortuous path and maintains spatial separation between fibres, preventing channelling and ensuring each fibre is in effective contact with flowing dialysate. This enhances diffusive solute clearance across the full membrane surface.
The F6 HPS dialyzer achieves urea clearance of approximately 186 mL/min at a blood flow rate of 200 mL/min and dialysate flow rate of 500 mL/min. At a blood flow rate of 300 mL/min, urea clearance increases to approximately 222 mL/min. Creatinine clearance at 200 mL/min blood flow is approximately 173 mL/min. These in vitro values are measured under standardised conditions (37°C, Hct 32%, protein 6 g/dL, dialysate flow 500 mL/min) per EN 1283/ISO 8637 standards. Actual in-vivo clearances may vary based on patient haematocrit, protein levels, and individual vascular access characteristics.
Fresenius F-series HPS dialyzers are dry-packaged (no pre-wetted storage fluid) due to the steam sterilisation process. Before use, the dialyzer requires priming with approximately 500 mL of sterile saline or bicarbonate dialysis solution to wet and prepare the membrane surface for blood contact. The priming procedure should follow the dialyzer's Instructions for Use and the dialysis machine's automatic priming programme. The short priming volume requirement of the F6 (82 mL blood compartment) is an advantage in patients where minimising extracorporeal circuit volume is clinically important.
Dialyzer surface area is selected primarily based on the patient's body surface area and the target dialysis dose (Kt/V ≥1.2 per KDOQI guidelines for three-times-weekly haemodialysis). Patients with larger body mass require more solute clearance, which can be achieved by increasing blood flow rate, dialysis session time, or dialyzer surface area. The F5 (1.0 m²) suits smaller patients; the F6 (1.3 m²) covers the average adult; the F7 (1.6 m²) and F8 (1.8 m²) are used for larger adults or in clinical protocols targeting higher clearances.
Standard anticoagulation for haemodialysis with polysulfone dialyzers including the F6 HPS uses unfractionated heparin (UFH) administered as a loading dose at session start followed by an infusion throughout the session to maintain anticoagulation of the extracorporeal circuit. In patients with heparin-induced thrombocytopenia (HIT) or other heparin contraindications, alternative anticoagulation protocols using citrate anticoagulation or argatroban are used. No-heparin dialysis is possible in patients with high bleeding risk, using pre-diluted saline flushes of the circuit at intervals, though this is less effective at preventing clotting. Confirm anticoagulation protocol with the prescribing nephrologist.
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