Fresenius Polysulfone F8 HPS Low-Flux Dialyzer
Pack Sizes Available
Product Description
Technical Specifications
- Membrane Material: Fresenius Polysulfone — microundulated hollow fibre structure; high endotoxin retention
- Flux Type: Low-flux
- Effective Membrane Area: 1.8 m²
- Priming Volume: Approximately 113 mL
- Ultrafiltration Coefficient (Kuf): Approximately 18 mL/h x mmHg
- Sterilisation: INLINE Steam sterilisation — no chemical residuals; housing: polycarbonate; potting: polyurethane
Frequently asked questions
The F8 (1.8 m²) is preferred over the F5 or F6 when: the patient has a high body surface area (BSA) requiring greater absolute solute clearance to achieve adequate Kt/V; the dialysis centre's protocol targets higher Kt/V values (>1.4) as a quality benchmark; session time is constrained and increased surface area compensates for shorter treatment times; or the patient consistently fails to achieve target Kt/V on a smaller dialyzer despite optimised blood and dialysate flow rates. The F8 is the standard 'large' dialyzer in the HPS range for these clinical scenarios.
The priming volume of 113 mL represents the blood volume that fills the hollow fibre blood compartment of the F8 dialyzer during a session. When dialysis starts, this volume of the blood circuit is initially filled with priming saline, and the transition from saline to blood at session commencement creates a transient haemodilution effect. For patients with poor haemodynamic tolerance or severe cardiovascular disease, this priming volume represents a meaningful addition to extracorporeal circuit blood volume that must be managed through the return at session end or through specific blood priming techniques. Smaller patients in particular may benefit from smaller-surface-area dialyzers with lower priming volumes for haemodynamic stability.
The F8 HPS achieves the following in vitro urea clearances per published data: approximately 190 mL/min at QB 200 mL/min; approximately 236 mL/min at QB 300 mL/min; and approximately 240 mL/min at QB 400 mL/min (with dialysate flow QD 500 mL/min at 37°C). The clearance plateau between 300 and 400 mL/min blood flow reflects the limiting effect of dialysate flow rate — increasing blood flow beyond the point where dialysate flow is rate-limiting provides diminishing marginal clearance returns. Increasing dialysate flow to 800 mL/min can recover additional clearance at higher blood flow rates.
The F8 HPS dialyzer housing is manufactured from polycarbonate, which provides optical clarity (allowing visual inspection of the blood in the dialyzer during the session) and adequate structural strength at dialysis operating pressures. The potting compound — the material that seals the hollow fibre bundle at each end of the dialyzer — is polyurethane. The header caps are polycarbonate. O-rings are silicone rubber. All materials are selected for biocompatibility and compatibility with the steam sterilisation process at the manufacturing stage. These are the same materials used across the F-series range.
The maximum allowable transmembrane pressure (TMP) for the F8 HPS dialyzer is 500 mmHg — the same as the F5 and F6. TMP is the pressure difference between the blood compartment and the dialysate compartment across the membrane, which is the driving force for ultrafiltration (fluid removal). With the F8's Kuf of approximately 18 mL/h x mmHg, a TMP of 500 mmHg would theoretically produce 9,000 mL/hour of ultrafiltration — far beyond any clinical requirement. In practice, TMP is set by the dialysis machine's volume-controlled ultrafiltration system at the level required to achieve the prescribed fluid removal rate, typically in the range of 20-100 mmHg for standard removal rates.
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