Colistimethate Sodium for Injection 2 MIU
Pack Sizes Available
Product Description
Technical Specifications
- Active Ingredient: Colistimethate Sodium (colistin prodrug)
- Strength: 2 MIU (2 Million International Units) per vial
- Dosage Form: Lyophilized powder for reconstitution
- Administration Route: Intravenous infusion
- Drug Class: Polymyxin antibiotic
- Storage Condition: Store below 25 degrees C, protect from light
- Shelf Life: 24 months from date of manufacture
- Primary Use Case: Hospital-acquired and multidrug-resistant gram-negative infections
The 2 MIU vial allows clinicians to reach typical adult dosing requirements without combining multiple smaller vials, which reduces preparation time and the risk of dosing errors during reconstitution in busy ICU settings. It remains a widely stocked strength across hospital pharmacies for exactly this reason.
Colistimethate is active against gram-negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, and Escherichia coli, particularly strains that have developed resistance to carbapenems and other frontline antibiotics. It has limited or no activity against gram-positive bacteria.
The most significant concerns are nephrotoxicity (kidney impairment) and neurotoxicity, which can present as dizziness, paraesthesia, or muscle weakness. Regular renal function monitoring is standard practice throughout treatment, and doses are adjusted based on creatinine clearance.
Yes, it is frequently used in combination regimens alongside other antibiotics such as carbapenems or aminoglycosides for severe multidrug-resistant infections, based on susceptibility testing and clinical judgment. Combination use is common precisely because resistant organisms often require more than one mechanism of attack.
Treatment duration depends on the site and severity of infection but commonly ranges from 7 to 14 days, guided by clinical response, repeat cultures, and inflammatory markers. The treating physician determines the exact duration based on the individual case.
The reconstituted solution should be visually inspected for particulate matter or discoloration before administration, and any vial showing abnormal appearance should not be used. Reconstituted solution should be administered within the timeframe specified on the product insert.
Caspofungin Acetate for Injection
Fungal infections rarely wait for the perfect moment. They show up in ICUs, in oncology wards, in patients whose immune systems are already fighting three other battles, and clinicians need an antifungal that works fast without adding a fourth problem to the list. Caspofungin Acetate belongs to the echinocandin class, and unlike the older azole and polyene antifungals, it goes after the fungal cell wall rather than the cell membrane, which gives it a cleaner safety profile in patients who are already on a stack of other medications. Each vial is supplied as a lyophilized powder that gets reconstituted before intravenous infusion. Dosing typically follows a single 70mg loading dose on day one, then 50mg daily thereafter, which is exactly why exporters who understand hospital procurement stock both strengths together rather than forcing a buyer to source them separately. It treats invasive candidiasis, candidemia, esophageal candidiasis, and invasive aspergillosis in patients who haven't responded to or can't tolerate other therapies, making it a mainstay in tertiary care antifungal protocols across markets that import from India. What tends to matter most for an importer stocking this molecule is consistency between batches. Echinocandins are notoriously fussy to manufacture at scale, and a supplier who can't hold potency and reconstitution behavior steady from lot to lot creates real clinical risk downstream. We work with WHO-GMP compliant manufacturing partners who maintain tight cold-chain discipline from lyophilization through final packing, because a vial that arrives even slightly out of spec is a vial a hospital pharmacy will reject on sight. Regulatory paperwork for critical care antifungals gets scrutinized more than most, so every batch ships with a complete dossier: certificate of analysis, stability data, GMP certification, and where required, a free sale certificate that clears customs without the back-and-forth that stalls shipments for weeks. That documentation discipline, paired with flexible minimum order quantities that don't force smaller distributors into warehousing more stock than they can move, is what keeps repeat buyers coming back rather than shopping around every quarter. Fifteen years of exporting critical care injectables from India has taught us that price matters, but reliability of supply matters more when a hospital's antifungal stewardship program depends on a molecule actually being on the shelf when it's needed. Communication stays direct and personal rather than routed through layers of account managers, so questions about batch availability, lead times, or documentation get answered by someone who actually knows the shipment, not a call center script. For distributors serving hospital pharmacies, oncology centers, and critical care units, Caspofungin Acetate represents one of those products where the margin on any single vial is modest but the relationship built around dependable supply pays off across every reorder cycle that follows.
Colistimethate Sodium for Injection 1 MIU
There is a certain irony in colistin's comeback story. A drug developed in the 1950s, largely shelved for decades because of its reputation for kidney toxicity, is now one of the last reliable options standing against multidrug-resistant gram-negative bacteria that shrug off almost everything newer. Hospitals reach for Colistimethate Sodium when Klebsiella, Pseudomonas, or Acinetobacter infections have outmanoeuvred the usual carbapenem lineup, which places this product firmly in the last-line antibiotic category rather than a routine one. Colistimethate is the inactive prodrug form of colistin, converted to its active state in the body after administration, and the 1 MIU vial represents the smaller of the commonly stocked strengths, useful for weight-based dosing in patients where a full higher-strength vial would overshoot the calculated requirement. It's supplied as a lyophilized powder reconstituted before intravenous infusion, and correct reconstitution matters more here than with most antibiotics given the narrow therapeutic window between an effective dose and one that stresses the kidneys. For an exporter, colistin is not a casual product line. Regulatory bodies worldwide have tightened oversight on it precisely because of its toxicity profile and its status as a treatment of last resort, which means importers expect airtight documentation before they will even quote a price to their own institutional buyers. Every batch we supply travels with full analytical certification, stability data, and manufacturing traceability, because a tender for a critical care antibiotic will get rejected outright if the paperwork has gaps. Cold chain handling from the point of lyophilization to the point of delivery is non-negotiable, and we treat it that way rather than as a checkbox. Distributors serving ICUs and infectious disease units don't have room for a shipment that arrives compromised, not when the patients receiving it are often already critically ill with limited remaining treatment options. One pattern we've noticed working with importers over 15 years is that colistin orders tend to come in waves tied to local resistance patterns and hospital tender cycles rather than steady month-to-month demand, so we keep flexible MOQs and don't force distributors to warehouse more than their actual pipeline calls for. Communication stays direct between our team and the buyer, without layers of intermediaries slowing down quotes or documentation requests. For wholesalers and hospital suppliers building out a critical care antibiotic portfolio, Colistimethate Sodium 1 MIU fills a specific and important gap, and getting it from a partner who understands both the pharmacology and the paperwork saves headaches that a lower price alone never will.
Clarithromycin for Injection 500mg
A patient who can't swallow a tablet still needs their pneumonia treated, and that's the entire reason Clarithromycin exists in injectable form. Oral clarithromycin has been a workhorse macrolide antibiotic for decades, but hospitalised patients on ventilators, those in post-surgical recovery, or anyone with a compromised gut can't rely on a pill making it past the stomach lining, which is where the IV formulation earns its place on the hospital formulary. Each 500mg vial contains clarithromycin lactobionate, reconstituted first with sterile water and then diluted further before administration as a slow IV infusion, never as a bolus injection and never intramuscularly. It's indicated for community-acquired pneumonia, bacterial bronchitis, and skin or soft tissue infections where oral therapy isn't practical, and it retains the broad gram-positive and gram-negative coverage that makes macrolides useful across a wide range of respiratory infections. The reconstitution chemistry on this molecule is genuinely finicky. It requires the correct diluent in the correct sequence, or the solution precipitates, and a batch that doesn't dissolve cleanly is a batch a hospital pharmacist sends straight back. We work with manufacturers who've refined their lyophilization and fill process specifically to avoid this problem, which sounds like a minor technical point until you're the distributor explaining to a hospital why half a shipment came back. For importers stocking hospital antibiotic ranges, having a supplier who can move quickly on documentation matters just as much as the product itself. Every batch we export ships with certificate of analysis, GMP compliance certification, and stability data covering the full claimed shelf life, so customs clearance and hospital pharmacy intake don't stall waiting on missing paperwork. Flexible order quantities mean a smaller regional distributor can stock a reasonable volume without committing to a container load they can't move before expiry. What distinguishes Clarithromycin for Injection from some of the flashier newer antibiotics is that demand for it is steady rather than spiky, tied to routine respiratory infection season rather than resistance outbreaks, which makes it a dependable, predictable line item for a distributor building a recurring order pattern. After 15 years exporting hospital-grade injectables from India, that predictability is exactly the kind of product relationship that keeps a partnership going year after year, backed by clear communication and delivery timelines a buyer can actually plan around. For hospital suppliers and pharmaceutical wholesalers rounding out a respiratory antibiotic portfolio, this 500mg vial fills the gap between oral therapy and the heavier IV antibiotics reserved for resistant infections.